Politics was inherited by Manpreet Singh, his father Sardar Gurcharanjit Singh was the Sarpanch of the village from 1982 to 1997 and also served as the President of the Cooperative Society in his village. Manpreet Singh Ayali also started his political journey after becoming the President of the Cooperative Society, after which he was elected as the Sarpanch of the village. Later on, he was elected as a member of the Zila Parishad. In 2008, Manpreet Singh Ayali became the youngest Zila Parishad, Chairman. After that, he was elected MLA from Halka Dakha on Shiromani Akali Dal ticket in 2012. He also contested from Lok Sabha constituency Ludhiana in 2014 on behalf of the party. He also served as a member of the Punjab Pollution Control Board, State Health Planning Monitoring Committee.
Manpreet Singh Ayali was elected MLA for the second time after defeating Sandeep Singh Sandhu, OSD of Chief Minister Capt. Amarinder Singh in the by-elections held in 2019 due to the resignation of Harwinder Singh Phoolka.
In Shiromani Akali Dal, he started his journey as a worker. With his commitment to the party, he went on to become the General Secretary of Youth Akali Dal. After that, the party gave him the responsibility of Senior Vice President of Youth Akali Dal. He also served as the Coordinator of Youth Akali Dal, Ludhiana. After that, he became the General Secretary in Shiromani Akali Dal.

During his tenure, Manpreet Singh Ayali not only secured huge grants from the State Government and Central Government for the development of the Constituency but also did his best to take the constituency to new heights by taking grants from the World Bank. Manpreet Singh Ayali is also credited with making necessary amendments in the rules to remove the legal hurdles in the way of getting the funds to be spent for the development of the villages from the schemes.